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Case-Based Medicine Teaching Series
Acid-Related Disorders
Release
Date: October 2003
Expiration Date: October 31, 2004
| NEEDS
STATEMENT |
Gastroesophageal
reflux disease (GERD) is one of the most prevalent gastrointestinal
disorders, affecting an estimated 5% to 7% of the global population.
Although common, GERD often is unrecognized because its symptoms may
be misunderstood and improperly treated or self-treated. GERD is generally
a treatable disease; however, serious complications can result if
it is not treated properly. Various methods to treat GERD effectively
range from lifestyle measures to the use of medication or surgical
procedures.
It is essential for clinicians who treat individuals with persistent
heartburn or other chronic and recurrent symptoms of GERD to determine
an accurate diagnosis and prescribe the most effective treatment available.
This monograph describes a variety of cases involving GERD and illustrates
the clinicians process from patient presentation through diagnosis
to treatment and management. |
| TARGET
AUDIENCE |
| This
educational program is intended for primary care physicians and physicians
who deal with acid-related disorders. |
| LEARNING
OBJECTIVES |
At
the completion of this activity, participants should be able to:
| 1.
|
Describe
signs and symptoms of supraesophageal gastroesophageal reflux
disease (GERD) in childhood, as well as discuss management strategies.
|
| 2. |
Recognize the signs and symptoms of dyspepsiaboth refractory
and severeand the optimal medical treatment.
|
| 3.
|
Discuss
the differences between nonerosive reflux disease (NERD), nonerosive
esophageal disorders (NEEDs), and GERD.
|
| 4.
|
Discuss the progression of GERD from erosive esophagitis to
adenocarcinoma.
|
| 5.
|
Identify
risk factors for the development of gastrointestinal events
associated with the use of nonsteroidal anti-inflammatory drugs
(NSAIDs).
|
| 6. |
Discuss optimal management, including prophylactic therapy,
of the patient on concurrent NSAID therapy.
|
|
| ACCREDITATION
STATEMENT |
| This
activity has been planned and implemented in accordance with the Essential
Areas and policies of the Accreditation Council for Continuing Medical
Education through the joint sponsorship of the Dannemiller Memorial
Educational Foundation and McMahon Publishing Group. The Dannemiller
Memorial Educational Foundation is accredited by the ACCME to provide
continuing medical education for physicians. |
| DESIGNATION
STATEMENT |
|
The Dannemiller
Memorial Educational Foundation designates this educational activity
for a maximum of 3 category 1 credits toward the AMA Physicians
Recognition Award. Each physician should claim only those credits
that he/she actually spent in the activity.
|
| METHOD
OF PARTICIPATION |
|
This activity
should take approximately 3 hour(s) to complete. The participant
should, in order, read the objectives and monograph, answer the
online multiple-choice post-test, and complete the answer form,
registration, and evaluation. This credit is valid through October
31, 2004.
For questions
regarding the content of this activity, contact Dannemiller Memorial
Educational Foundation, accredited provider for this CME/CE activity,
at edd@pain.com. For
technical assistance, contact support@cecity.com.
|
| DISCLOSURE
OF UNLABELED USE |
|
This educational
activity contains discussion of published and/or investigational
uses of prokinetic agents for the treatment of GERD in children;
tricyclic antidepressants, tegaserod, alosetron, and cilansetron
for the treatment of NEED; high-dose proton pump inhibitor (PPI)
therapy for the treatment of erosive esophagitis; ablative therapiesthermal,
chemical, or mechanicalfor Barretts esophagus; and omeprazole,
lansoprazole, buspirone, sumatriptan, domperidone, and tricyclic
antidepressants for the treatment of functional dyspepsia. Some
uses of these agents have not been approved by the FDA. Please refer
to the official prescribing information for each product for discussion
of approved indications, contraindications, and warnings.
|
| FACULTY |
Colin W. Howden, MD
Series Editor
Professor of Medicine, Division of Gastroenterology, Northwestern
University
Feinberg School of Medicine, Chicago, Illinois.
Dr. Howden has disclosed that he is a consultant for TAP Pharmaceuticals,
Takeda, Novartis, Wyeth, Allergen, and Schwarz Pharma. He is on the
speakers bureau for TAP Pharmaceuticals, AstraZeneca, Merck,
Novartis, and Wyeth. Dr. Howden is an investigator for Merck and Takeda.
Benjamin D. Gold, MD
Associate Professor of Pediatrics and Microbiology, Division of Pediatric
Gastro-enterology and Nutrition, Emory University School of Medicine,
Atlanta, Georgia.
Dr. Gold has disclosed that he is a consultant and on the speakers
bureau for TAP Pharmaceuticals, AstraZeneca, and Prometheus. He has
received an honorarium from TAP Pharmaceuticals.
Joel H. Rubenstein, MD
Fellow, Department of Internal Medicine, Division of Gastroenterology,
University of Michigan Health System, Ann Arbor, Michigan.
Dr. Rubenstein has no financial information to disclose.
William D. Chey, MD
Associate Professor, Department of Internal Medicine, Division of
Gastroenterology, University of Michigan Health System, Ann Arbor,
Michigan.
Dr. Chey has disclosed that he is a consultant for AstraZeneca, Janssen,
and TAP Pharmaceuticals. He has received a research grant from AstraZeneca
and Janssen; he is on the speakers bureau for TAP Pharmaceuticals.
David C. Metz, MD
Professor of Medicine, Division of Gastroenterology, University of
Pennsylvania Health System, Philadelphia, Pennsylvania.
Dr. Metz has disclosed he is a consultant for AstraZeneca, TAP Pharmaceuticals,
and Wyeth. He is on the speakers bureau for AstraZeneca, TAP
Pharmaceuticals, and Wyeth. Dr. Metz has received grant support from
AstraZeneca, TAP Pharmaceuticals, and Wyeth.
John E. Pandolfino, MD
Assistant Professor of Medicine, Division of Gastroenterology, Northwestern
University
Feinberg School of Medicine, Chicago, Illinois.
Dr. Pandolfino has disclosed that he has no financial affiliation
with any pharmaceutical company.
Michael P. Jones, MD
Associate Professor of Medicine, Director, Gastroenterology and Physiology
Laboratory, Division of Gastroenterology, Northwestern University
Feinberg School of Medicine, Chicago, Illinois.
Dr. Jones has disclosed that he has no financial affiliation with
any pharmaceutical company.
Mae F. Go, MD
Chief, Gastrointestinal Section, Veterans Administration Salt Lake
City Health Care System, Salt Lake City, Utah.
Dr. Go has disclosed that she is on the speakers bureau for
AstraZeneca, TAP Pharmaceuticals, Merck, Wyeth, and Janssen.
A. Mark Fendrick, MD
Professor, Department of Internal Medicine, Division of General Medicine,
University of Michigan, Ann Arbor, Michigan.
Dr. Fendrick has disclosed that he is a consultant and on the speakers
bureau for TAP Pharmaceuticals, AstraZeneca, Merck, McNeill, and Procter
& Gamble.
David A. Peura, MD
Professor of Medicine, Associate Chief of Gastroenterology and Hepatology,
University of Virginia Health Systems, Charlottesville, Virginia.
Dr. Peura has disclosed that he is on the speakers bureau for
TAP Pharmaceuticals, AstraZeneca, Merck, and Wyeth.
Virender K. Sharma, MD
Associate Professor of Medicine, Mayo Clinic, Scottsdale, Arizona.
Dr. Sharma has disclosed that he on the speakers bureau and
has received research grants from TAP Pharmaceuticals. |
Jointly
sponsored by the Dannemiller Memorial Educational Foundation and McMahon
Publishing Group.
To access the Dannemiller site
please click on the logo.
|
 |
This activity is made possible by an unrestricted
educational grant from TAP Pharmaceuticals.

|
| DISCLAIMER |
|
The McMahon
Publishing Group, New York City © 2003.
All rights reserved. No part of this publication may be reproduced,
stored in a retrieval system, or transmitted, in any form or by
any meanselectronic, mechanical, photocopying, recording,
or otherwisewithout prior permission of the copyright owner.
The use of general descriptive names, trade names, trademarks, etc,
in this publication, even if they are not specially identified,
is not to be taken as a sign that such names, as understood by the
Trade Marks and Merchandise Marks Act, may accordingly be used freely
by anyone.
While the advice and information in this book are believed to be
true and accurate at the date of going to press, neither the authors
nor the editors nor the publisher can accept any legal responsibility
for any errors or omissions that may have been made. The publisher
makes no warranty, expressed or implied, with respect to material
contained herein.
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